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Preparative chromatography, a method used to separate and purify target compounds from complex mixtures, plays a crucial role in both the chemical and pharmaceutical industries.
In the chemical industry, preparative chromatography is used to isolate and purify desired compounds, removing impurities and contaminants that can affect the quality and performance of the end product. This is particularly important in industries that produce specialty chemicals, fine chemicals, and pharmaceutical intermediates where high purity is required.
In the pharmaceutical industry, preparative chromatography plays a vital role in the drug discovery and development process. It is used to isolate and purify active pharmaceutical ingredients (APIs) from natural sources or for the separation of enantiomers in chiral drug development.
In either industry, preparative chromatography has roles in the early stages of drug development, pilot studies, and process development. At Gilson, we provide support throughout this whole process and enable our customers and partners to achieve their purification goals from the milligrams to the kilogram scale.
By pioneering high throughput purification during the Combinatorial Chemistry era, Gilson has spearheaded the development of state-of-the-art purification platforms and software that today support CROs and biotech research and development groups in synthetic drug discovery.
Gilson’s VERITY® Preparative LC systems are highly effective in scaling up purification processes from a few milligrams to one gram of compound using a set of different chromatographic columns. This flexibility allows researchers to purify a hundred compounds per year in a reproducible way. VERITY® Preparative LC systems offer a range of features to enable researchers to purify compounds more efficiently and accurately. These features include the option for advanced fraction collection or post-purification liquid handling tasks via the powerful TRILUTION® LC software.
The modular aspect of the VERITY® system is usually a deciding factor when researchers choose a new LC system, as it allows excellent flexibility and the possibility to evolve with new project requirements. Upgrading an existing VERITY® system with mass detection can save researchers a lot of time by allowing them to identify and immediately collect the desired targeted product at high purity.
Figure 1. The VERITY Oligo Purification System is an example of a system with an all-in-one approach for continuous purification and analysis of reagent-grade nucleotides. The platform can be configured to meet your lab’s needs and budgets, offering capabilities from secure and robust purification to the continuous production of oligonucleotides. The modular system is also scalable to meet future requirements.
While preparative chromatography is widely used for the discovery of new active compounds, its ability to isolate compounds with unmatched levels of purity at larger scales makes this technology critical in the production of high-purity chemicals, pharmaceutical intermediates, and drug candidates. This high-quality separation ensures the safety and efficacy of final products in the chemical and pharmaceutical industries.
Gilson’s VERITY® SKID LC is designed to automatically manage all purification steps involved in process scale chromatography, such as generating elution mobile phases, injecting samples, detecting molecules, and collecting fractions. The unique design of this system makes it compatible with a large range of LC column sizes for HPLC and MPLC (High and Medium Pressure Liquid Chromatography, respectively), or CPC (Centrifugal Partition Chromatography) to optimize production throughput, costs, and quality.
Designed in multiple configurations, the VERITY® SKID LC includes advanced safety features that make it safe and compliant for non-GMP or cGMP pharmaceutical molecule purification processes.
In today's globalized world, businesses seeking industrial solutions often have a myriad of options available to them, including both local and international providers. While international providers may offer certain advantages, purchasing industrial solutions from local experts brings a host of benefits that go beyond cost considerations. From their specialized knowledge of the local market to their proximity, accessibility, and commitment to after-sales support, local experts offer a valuable proposition to businesses seeking industrial solutions. By engaging local experts, businesses not only gain access to tailored solutions but also contribute to local economic growth and foster stronger, more collaborative partnerships. Investing in the expertise of local providers is a strategic decision that can yield long-term advantages.
With Gilson, however, you don’t have to choose either an international partner or a local expert. You can have the best of both worlds: our international reach allows us to offer solutions to customers worldwide, yet our support and service teams gives our partners the ease and flexibility to work with local experts.
Preparative chromatography is an important technology for the chemical and pharmaceutical industries thanks to its ability to upscale the purification of compounds from research to production scale in a reproducible way. This feature is critical to ensure the safety and efficacy of fine chemicals, pharmaceutical intermediates, and drug candidates.
Gilson Purification Solutions are designed to meet the specific needs and challenges of customers in research and process scales. Additionally, these solutions can be tailored to meet the unique requirements of each customer’s business goals. VERITY® purification systems come with a dedicated team of local experts who ensure a smooth initial setup to training and comprehensive assistance to ensure that customers receive the support they need throughout their journey.
Selecting a partner that brings a host of benefits, including superior products and services, customization, seamless implementation, and streamlined processes, contributes to the customer's growth, profitability, and overall success in their industry. At Gilson, we strive to foster a collaborative relationship with our partners to build trust and grow together.
Preparative HPLC plays a crucial role in many industries. It’s used to isolate and purify desired compounds, removing impurities and contaminants that can affect the quality and performance of the end product.Weprovideyou with a unique value by helping you achieve your goals in all stages of development. From the early stages of drug development to scaling up to process development, where the batches of final compounds or intermediates are produced at kilogram scale, we support you at every step.
